I still remember when I read House of the Scorpion a few years ago. It was one of those books that was scary because of the potential for the science to be true one day.
Both House of the Scorpion and Lord of Opium raise questions about medical ethics, which I find to be fantastic conversation, and the nature of the soul. In Lord of Opium, Matt mentions that because El Patron died, he now has a soul. So what did he have beforehand? I think both this Lord of Opium and The Unwind Dystology are fantastic pieces for conversation with adolescents on these topics.